2 Results for "

Hu5A8

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Hu5A8" in MCE Product Catalog:

  • Targets Recommended:
Ieramilimab
Ieramilimab
0 Images
Cat. No.: HY-P99027
CAS No.: 2137049-37-5
Synonyms: LAG525; IMP701; Hu5A8

Target:  

LAG-3

Research Areas:  

Cancer

Ieramilimab (LAG525; IMP701) is a humanized IgG4 monoclonal antibody that binds to LAG-3, resulting in inhibition of LAG-3 interaction with MHC-II molecules. Ieramilimab restores T-cell and NK-cell-mediated antileukemic immunity by reducing exhaustion and augmenting cytokine output and cytotoxicity. Ieramilimab increases the infiltration of cytotoxic T lymphocytes and reduces baseline densities of regulatory T cells (Tregs) and ADAM10-expressing tumor cells. Ieramilimab can be used for the study of various malignancies including melanoma, RCC, and advanced solid tumors .
loading...
    loading...
View All Sizes
TNX-1500
TNX-1500
0 Images
Cat. No.: HY-P991921

Target:  

TNF Receptor Fc Receptor (FcR)

Research Areas:  

Cardiovascular Disease Endocrinology

TNX-1500 is a crystallizable fragment-modified anti-CD154 antibody. TNX-1500 contains the hu5c8 fragment antigen-binding (Fab) domain from Ruplizumab (HY-P99315) and an IgG4 Fc region engineered to reduce FcγRIIa binding. TNX-1500 has significantly weaker binding affinity to FcγRI, FcγRIIaH, FcγRIIbF, FcγRIIIaF, and FcγRIIIaV compared to hu5c8 (Kd values: 8.7 nM, 7100 nM, 4900 nM, 8000 nM, 6000 nM respectively). TNX-1500 prolongs nonhuman primate renal allograft survival, prolongs nonhuman primate cardiac allograft survival. TNX-1500 can be used for the research of allograft rejection [1] [2].
loading...
    loading...
View All Sizes
Assay Types