1 Result for "

IB001

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "IB001" in MCE Product Catalog:

Cat. No.: HY-P992379
Synonyms: BAG3-H2L4

Target:  

Bcl-2 Family

Research Areas:  

Cancer

IB001 is a humanized anti-BAG3 antibody that inhibits BAG3, with a KD value of 14.4 nM for human BAG3. IB001 blocks BAG3-dependent monocyte/macrophage activation, interferes with the interaction between BAG3 and IFITM-2, and disrupts tumor microenvironment signaling pathways. IB001 inhibits tumor growth, reduces α-SMA-positive fibroblasts, and blocks BAG3-dependent IL-6 release. IB001 accumulates in a time-dependent manner in pancreatic ductal adenocarcinoma tumors. IB001 can be used for research related to pancreatic ductal adenocarcinoma .
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