2 Results for "

ICI174864

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "ICI174864" in MCE Product Catalog:

Cat. No.: HY-101230
CAS No.: 89352-67-0
Purity:  99.97%
Target:  

Opioid Receptor

Research Areas:  

Neurological Disease

ICI 174864 is a selective and brain-penetrant δ-opioid receptor antagonist with Ke values of 22.0 nM to 30.6 nM at δ-opioid receptor in mouse vas deferens. ICI 174864 selectively blocks biological effects mediated by the δ-opioid receptor agonist DPDPE (HY-P1334) after central administration. ICI 174864 reverses hypotension in rats with endotoxic shock and inhibits acetic acid-induced writhing in mice. ICI 174864 can be used for the research of opioid receptor subtypes, endotoxic hypotension and analgesic pathways .
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Cat. No.: HY-P1617
CAS No.: 105496-35-3
Target:  

Endogenous Metabolite

Research Areas:  

Neurological Disease

LY 190388 is a penicillamine-containing enkefa peptide analog with μ receptor agonist activity. LY 190388 showed analgesic effect in inhibiting the writhing response in mice after intracerebroventricular administration. The analgesic effect of LY 190388 is not caused by its δ receptor agonist action, but by its μ receptor agonist activity. When LY 190388 is used together with the δ receptor antagonist ICI 174864, an additive analgesic effect is produced .
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