89352-67-0
Chemical Structure
ICI 174864
- CAS. Nr.: 89352-67-0
- Formula:C34H46N4O6
- Molecular Weight:606.75
IUPAC Name: (2-((S)-2-(diallylamino)-3-(4-hydroxyphenyl)propanamido)-2-methylpropanoyl)-L-phenylalanyl-L-leucine
InChIKey: BGJPRBZZLWCLJW-AWCRTANDSA-N
SMILES: C=CCN(CC=C)[C@H](C(NC(C)(C)C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC1=CC=CC=C1)=O)=O)CC2=CC=C(C=C2)O
Biological Activity: ICI 174864 is a selective and brain-penetrant δ-opioid receptor antagonist with Ke values of 22.0 nM to 30.6 nM at δ-opioid receptor in mouse vas deferens. ICI 174864 selectively blocks biological effects mediated by the δ-opioid receptor agonist DPDPE (HY-P1334) after central administration. ICI 174864 reverses hypotension in rats with endotoxic shock and inhibits acetic acid-induced writhing in mice. ICI 174864 can be used for the research of opioid receptor subtypes, endotoxic hypotension and analgesic pathways[1][2][3][4][5].
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ICI 174864 | 98.84% | ICI 174864 is a selective and brain-penetrant δ-opioid receptor antagonist with Ke values of 22.0 nM to 30.6 nM at δ-opioid receptor in mouse vas deferens. ICI 174864 selectively blocks biological effects mediated by the δ-opioid receptor agonist DPDPE (HY-P1334) after central administration. ICI 174864 reverses hypotension in rats with endotoxic shock and inhibits acetic acid-induced writhing in mice. ICI 174864 can be used for the research of opioid receptor subtypes, endotoxic hypotension and analgesic pathways. | ||||||||||||||||||||
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References
- [1]. Dray A, et al. Selective delta-opioid receptor antagonism by ICI 174,864 in the central nervous system. Peptides. 1984;5(5):1015-1016. [Content Brief]
- [2]. van der Meer JW, et al. Abstract!. Neth J Med. 2002;60(11):418. [Content Brief]
- [3]. Jackson HC, et al. Hyperphagia induced by 2-deoxy-D-glucose in the presence of the delta-opioid antagonist ICI 174,864. Neuropharmacology. 1985;24(8):815-817. [Content Brief]
- [4]. Cotton R, et al. ICI 174864: a highly selective antagonist for the opioid delta-receptor. Eur J Pharmacol. 1984 Jan;97(3-4):331-332.
