N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu
N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu is a compound that can antagonize the δ-opioid receptor and the action of [D-Pen2,D-Pen ] enkephalin in vivo. Its antagonistic effect can be verified by specific behavioral experiments.
For research use only. We do not sell to patients.
- CAS No.: 92535-15-4
- Formula: C38H53N5O7
- Molecular Weight:691.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Opioid Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
116 nM
Compound: ICI-174864
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Inverse agonist activity at human DOR expressed in CHO cell membranes by [35S]GTPgammaS binding assay
Inverse agonist activity at human DOR expressed in CHO cell membranes by [35S]GTPgammaS binding assay
|
[PMID: 26048798] |
| CHO | IC50 |
18900 nM
Compound: ICI-174864
|
Binding affinity was measured in cloned Opioid receptor mu 1 expressed in CHO cells using [3H]- DAMGO as radioligand.
Binding affinity was measured in cloned Opioid receptor mu 1 expressed in CHO cells using [3H]- DAMGO as radioligand.
|
[PMID: 11052799] |
| CHO | IC50 |
703 nM
Compound: ICI-174864
|
Binding affinity was measured in cloned Opioid receptor delta 1 expressed in CHO cells using [3H]- DPDPE as radioligand.
Binding affinity was measured in cloned Opioid receptor delta 1 expressed in CHO cells using [3H]- DPDPE as radioligand.
|
[PMID: 11052799] |
| CHO | IC50 |
83 nM
Compound: 22, ICI-174864
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Inverse agonist activity at human cloned delta opioid receptor expressed in CHO cells assessed as inhibition of DPDPE-stimulated [35S]GTP-gamma-S binding in presence of 1 uM GDP
Inverse agonist activity at human cloned delta opioid receptor expressed in CHO cells assessed as inhibition of DPDPE-stimulated [35S]GTP-gamma-S binding in presence of 1 uM GDP
|
[PMID: 16942033] |
Chemical Information
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CAS No. 92535-15-4
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Molecular Weight 691.86
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Formula C38H53N5O7
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Sequence
{N,N-Diallyl}-Tyr-{Aib}-{Aib}-Phe-Leu
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Sequence Shortening
{N,N-Diallyl}-Y-{Aib}-{Aib}-F-Leu
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)