2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu

N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu is a compound that can antagonize the δ-opioid receptor and the action of [D-Pen2,D-Pen ] enkephalin in vivo. Its antagonistic effect can be verified by specific behavioral experiments.

For research use only. We do not sell to patients.

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N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu

N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu Chemical Structure

CAS No. : 92535-15-4

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N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu is a compound that can antagonize the δ-opioid receptor and the action of [D-Pen2,D-Pen ] enkephalin in vivo. Its antagonistic effect can be verified by specific behavioral experiments.

Cellular Effect
Cell Line Type Value Description References
CHO EC50
116 nM
Compound: ICI-174864
Inverse agonist activity at human DOR expressed in CHO cell membranes by [35S]GTPgammaS binding assay
Inverse agonist activity at human DOR expressed in CHO cell membranes by [35S]GTPgammaS binding assay
[PMID: 26048798]
CHO IC50
18900 nM
Compound: ICI-174864
Binding affinity was measured in cloned Opioid receptor mu 1 expressed in CHO cells using [3H]- DAMGO as radioligand.
Binding affinity was measured in cloned Opioid receptor mu 1 expressed in CHO cells using [3H]- DAMGO as radioligand.
[PMID: 11052799]
CHO IC50
703 nM
Compound: ICI-174864
Binding affinity was measured in cloned Opioid receptor delta 1 expressed in CHO cells using [3H]- DPDPE as radioligand.
Binding affinity was measured in cloned Opioid receptor delta 1 expressed in CHO cells using [3H]- DPDPE as radioligand.
[PMID: 11052799]
CHO IC50
83 nM
Compound: 22, ICI-174864
Inverse agonist activity at human cloned delta opioid receptor expressed in CHO cells assessed as inhibition of DPDPE-stimulated [35S]GTP-gamma-S binding in presence of 1 uM GDP
Inverse agonist activity at human cloned delta opioid receptor expressed in CHO cells assessed as inhibition of DPDPE-stimulated [35S]GTP-gamma-S binding in presence of 1 uM GDP
[PMID: 16942033]
Molecular Weight

691.86

Formula

C38H53N5O7
CAS No.
Sequence

{N,N-Diallyl}-Tyr-{Aib}-{Aib}-Phe-Leu
Sequence Shortening

{N,N-Diallyl}-Y-{Aib}-{Aib}-F-Leu
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu92535-15-4Opioid ReceptorInhibitorinhibitorinhibit

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