1 Result for "

IMG 008

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "IMG 008" in MCE Product Catalog:

Cat. No.: HY-P992384

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

IMG-008 is a fully human antagonistic antibody targeting IL-36R, acting as a high-affinity IL-36R inhibitor (Kd = 6.23 pM). IMG-008 competitively blocks the pro-inflammatory signaling pathway mediated by human IL-36R, inhibiting receptor activation and the production of inflammatory cytokines. IMG-008 suppresses Imiquimod (HY-B0180)-induced skin inflammation in humanized mice, and Fc modification increases its serum exposure and prolongs its half-life. IMG-008 can be used in studies related to IL-36R-mediated inflammatory diseases such as psoriasis .
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