1 Result for "

KB-5666

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "KB-5666" in MCE Product Catalog:

Cat. No.: HY-117578
CAS No.: 131916-69-3
Target:  

Endogenous Metabolite

Research Areas:  

Neurological Disease

KB 5666 is a benzoxazine derivative with lipid peroxidation inhibitory activity. KB 5666 showed protective effects against post-ischemic neuronal death. KB 5666 effectively protected CA1 neurons when injected 5 minutes before or immediately after ischemia. KB 5666 also showed a dose-dependent protective effect when injected within 1 hour after ischemia. KB 5666 effectively prevented the significant decrease in microtubule-associated protein 2 immunoreactivity within the dendritic field of CA1 pyramidal cells. KB 5666 prevented the decrease in [3H]PDBu binding activity in different layers of the CA1 region after ischemia. The application of KB 5666 showed the ability to improve the cellular and functional consequences of ischemia .
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