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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
38 Results for "
KDM1
" in MedChemExpress (MCE) Product Catalog:
Products (38)
38 Results for "KDM1" in MCE Product Catalog:
19
19 Publications Verification
製品番号: HY-18632
CAS 番号: 1401966-69-5
Target:
研究分野:
GSK2879552 an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/ KDM1A), with potential antineoplastic activity [1] .
19
19 Publications Verification
製品番号: HY-18632A
CAS 番号: 1902123-72-1
Target:
研究分野:
GSK2879552 dihydrochloride an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), with potential antineoplastic activity [1] .
11
Target:
研究分野:
Seclidemstat is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat can be used for the research of Ewing Sarcoma [1] .
11
Target:
研究分野:
Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma [1] .
7
7 Cited Publications
別名: ORY-1001 dihydrochloride; RG6016 dihydrochloride; RO 7051790 dihydrochloride
Target:
研究分野:
Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor.
7
Target:
研究分野:
Iadademstat (ORY-1001) is a highly potent, orally active and selective LSD1 (KDM1A) inhibitor with antileukemic activity. Iadademstat can be used for relapsed or refractory acute myeloid leukemia research [1].
2
2 Cited Publications
Target:
研究分野:
TAK-418 is a selective, orally active LSD1 (KDM1A) enzyme inhibitor with an IC50 of 2.9 nM. TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models [1] .
1
1 Cited Publications
製品番号: HY-19612A
CAS 番号: 1831167-98-6
Target:
研究分野:
DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM [1].
1
1 Cited Publications
製品番号: HY-P75551
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: Lysine-specific histone demethylase 1A; KDM1A; AOF2; KDM1; KIAA0601; LSD1
Species:
Source:
製品番号: HY-RS07205
Target:
研究分野:
KDM1A Human Pre-designed siRNA Set A contains three designed siRNAs for KDM1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS07208
Target:
研究分野:
KDM1B Human Pre-designed siRNA Set A contains three designed siRNAs for KDM1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-147901
CAS 番号: 2938990-92-0
Target:
研究分野:
KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC50 values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC50 values of 16.34, 3.45 and 7.79 μM, respectively [1].
製品番号: HY-19612B
Target:
研究分野:
DDP-38003 trihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM.
製品番号: HY-RS07207
Target:
研究分野:
Kdm1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-19612
CAS 番号: 1831167-97-5
Target:
研究分野:
DDP-38003 (Compound 15) is an orally active KDM1A/LSD1 inhibitor with an IC50 value of 84 nM. DDP-38003 exhibits anticancer activity against promyelocytic leukemia [1].
製品番号: HY-RS07206
Target:
研究分野:
Kdm1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-143238
Target:
研究分野:
FY-56 is a highly potent and selective LSD1/KDM1A inhibitor (IC50=42 nM) and exhibits high selectivity over MAO-A/B. FY-56 induces differentiation of MOLM-13 and MV4-11 cell and has the potential for AML research [1].
製品番号: HY-123577
CAS 番号: 2098621-17-9
Target:
研究分野:
TPC-144 is a LSD1/KDM1A inhibitor. TPC-144 inhibits LSD1, and leads to a decrease in the protein level of DNMT1, causing low methylation of the LINE-1 element. TPC-144 can also produce a synergistic effect with Decitabine (HY-A0004) (a DNMT inhibitor), jointly promoting DNA demethylation and thereby inducing differentiation and apoptosis of leukemia cells. TPC-144 has also demonstrated anti-tumor efficacy in acute myeloid leukemia (AML) models. TPC-144 can be used for the study of AML [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
