1401966-69-5
1401966-69-5
Chemical Structure
GSK2879552
- CAS No.: 1401966-69-5
- Formula:C23H28N2O2
- Molecular Weight:364.48
IUPAC Name: 4-((4-((((1R,2S)-2-phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoic acid
InChIKey: LRULVYSBRWUVGR-FCHUYYIVSA-N
SMILES: O=C(O)C1=CC=C(CN2CCC(CN[C@H]3[C@H](C4=CC=CC=C4)C3)CC2)C=C1
Biological Activity: GSK2879552 an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/ KDM1A), with potential antineoplastic activity[1][2].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
GSK2879552 | 99.98% | GSK2879552 an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/ KDM1A), with potential antineoplastic activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.97
HY-18632AGSK2879552 dihydrochloride -
Similarity Score 0.79
HY-131970LSD1/HDAC6-IN-1 -
Similarity Score 0.60
HY-100155R4-IBP (Standard) -
Similarity Score 0.60
HY-186116ALSD1-IN-49 hydrochloride -
Similarity Score 0.60
HY-186116LSD1-IN-49 -
Similarity Score 0.58
HY-151368AChE/BChE-IN-10 -
Similarity Score 0.58
HY-150503KH-259 -
Similarity Score 0.57
HY-153002p38α inhibitor 3 -
Similarity Score 0.57
HY-W0749572-(1-Benzylpiperidin-4-yl)acetic acid -
Explore the MedChemAI to find more analogs
References
- [1]. Huang M, et al. Targeting KDM1A attenuates Wnt/β-catenin signaling pathway to eliminate sorafenib-resistant stem-like cells in hepatocellular carcinoma. Cancer Lett. 2017 Apr 2;398:12-21 [Content Brief]
- [2]. Mohammad HP, et al. A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell. 2015 Jul 13;28(1):57-69. [Content Brief]
