TPC-144
TPC-144 is a LSD1/KDM1A inhibitor. TPC-144 inhibits LSD1, and leads to a decrease in the protein level of DNMT1, causing low methylation of the LINE-1 element. TPC-144 can also produce a synergistic effect with Decitabine (HY-A0004) (a DNMT inhibitor), jointly promoting DNA demethylation and thereby inducing differentiation and apoptosis of leukemia cells. TPC-144 has also demonstrated anti-tumor efficacy in acute myeloid leukemia (AML) models. TPC-144 can be used for the study of AML.
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- CAS. Nr.: 2098621-17-9
- Formel: C31H31F2N3O2
- Molecular Weight:515.59
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Chemical Information
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CAS. Nr. 2098621-17-9
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Molecular Weight 515.59
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Formel C31H31F2N3O2
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SMILES
N[C@H]1C[C@H]2CC[C@@H](C1)N2C(C3=CC(C4=CC=C(C(F)=C4)C#N)=C(C=C3)C5=CC=C(C=C5F)CC(O)(C)C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TPC-144 Related Classifications
HY-123577 Related Classifications
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