2938990-92-0
Chemical Structure
KDM1/CDK1-IN-1
- CAS No.: 2938990-92-0
- Formula:C22H17N5O3S
- Molecular Weight:431.47
IUPAC Name: ethyl 3-(benzo[d]thiazol-2-yl)-7-hydroxy-2-(phenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylate
InChIKey: GEWPBWACSLRWAD-UHFFFAOYSA-N
SMILES: O=C(C1=C(O)N2C(N=C1)=C(C3=NC4=CC=CC=C4S3)C(NC5=CC=CC=C5)=N2)OCC
Biological Activity: KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC50 values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC50 values of 16.34, 3.45 and 7.79 μM, respectively[1].
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KDM1/CDK1-IN-1 | KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC50 values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC50 values of 16.34, 3.45 and 7.79 μM, respectively. | |||||||||||||||||||||
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