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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
LPAR1 antagonist
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "LPAR1 antagonist" in MCE Product Catalog:
Cat. No.: HY-162267
CAS No.: 3032275-33-2
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LPAR1 antagonist 1 (compound 18) is a potent, oral active and selective LPAR1 antagonist with the IC50 of 3.3 nM. LPAR1 antagonist 1 can be used for study of fibrosis .
Cat. No.: HY-159983
CAS No.: 2750508-72-4
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GS-2278 is an LPAR1 (lysophosphatidic acid receptor 1) antagonist with potential for research in idiopathic pulmonary fibrosis (IPF) .
Cat. No.: HY-160661
CAS No.: 1664336-46-2
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LPAR1 antagonist 2 (example 76) is an LPAR1 antagonist with an average IC50 of 130 nM .
Cat. No.: HY-171806
CAS No.: 1257213-96-9
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BMT-136088 is a LPAR1 antagonist . 11C-BMT-136088 can be used as a positron emission tomography (PET) radioligand to quantify specific binding to LPA1 in lung.
Cat. No.: HY-120282
CAS No.: 1802079-45-3
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ONO-9910539 is a lysophosphatidic acid receptor 1 (LPAR1) antagonist. ONO-9910539 is applicable to the research of idiopathic pulmonary fibrosis .
Cat. No.: HY-184986
CAS No.: 2901868-37-7
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PIPE-791 is an orally active, blood-brain barrier-permeable selective antagonist of LPAR1. PIPE-791 inhibits LPA-induced calcium mobilization, collagen expression, histamine release, and the activation of fibroblasts, microglia and macrophages. PIPE-791 induces oligodendrocyte precursor cell differentiation, myelination and remyelination, and increases the number of microglia in the retina of normotensive rats. PIPE-791 protects mature oligodendrocytes from cytokine-induced death, reduces the levels of pulmonary fibrosis markers and alleviates neuroinflammation in preclinical models. PIPE-791 can be used in the research of glaucoma, neuroinflammatory diseases, chronic osteoarthritis pain, idiopathic pulmonary fibrosis and multiple sclerosis .
Cat. No.: HY-182787
CAS No.: 3057457-78-7
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LPA1 receptor antagonist-7 is a LPA1 antagonist. LPA1 receptor antagonist-7 blocks downstream signaling pathways mediated by LPA1. LPA1 receptor antagonist-7 inhibits LPA-induced migration and invasion of cancer cells. LPA1 receptor antagonist-7 can be used for the research of triple-negative breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
