LPA1 receptor antagonist-7
LPA1 receptor antagonist-7 is a LPA1 antagonist. LPA1 receptor antagonist-7 blocks downstream signaling pathways mediated by LPA1. LPA1 receptor antagonist-7 inhibits LPA-induced migration and invasion of cancer cells. LPA1 receptor antagonist-7 can be used for the research of triple-negative breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 3057457-78-7
- Formula: C28H27N5O3
- Molecular Weight:481.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
LPA1 receptor antagonist-7 (Compound 5f) (30 min) potently inhibits LPA1-mediated cAMP suppression in CHO-K1 cells overexpressing LPA1, with an IC50 of 215.2 nM[1].
LPA1 receptor antagonist-7 (30 min) potently inhibits LPA1-mediated calcium mobilization in HEK-293 cells stably expressing LPA1, with an IC50 of 7.9 nM[1].
LPA1 receptor antagonist-7 (0-20 μM; 48 h) potently inhibits LPA-induced migration of MDA-MB-231 triple-negative breast cancer cells, with an IC50 of 2.06 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:triple-negative breast cancer MDA-MB-231 cells
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Concentration:1, 5, 10 or
20 μM -
Incubation Time:48 h
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Result:Potently inhibited 18:1 LPA-induced cell migration, with an IC50 of 2.06 μM and 108.43% maximal inhibition of 10 μM 18:1 LPA response.\nDose-dependently blocked 18:1 LPA-induced cell migration and invasion, with significant inhibition observed at concentrations from 1 μM to 20 μM.
Chemical Information
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CAS No. 3057457-78-7
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Molecular Weight 481.55
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Formula C28H27N5O3
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SMILES
OC(C1(CC1)C(C=C2)=CC=C2C(C=C3)=CC=C3N4N=NC(C)=C4NC(N[C@H](C)C5=CC=CC=C5)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LPA1 receptor antagonist-7 Related Classifications
HY-182787 Related Classifications
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