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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
LPS binding pocket
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "LPS binding pocket" in MCE Product Catalog:
Cat. No.: HY-179371
CAS No.: 2606032-80-6
Target:
Research Areas:
LIQ1, a flavonoid derivative, is a potent Pyruvate kinase M2 (PKM2) allosteric inhibitor (IC50 = 0.39 μM; Kd = 4.5 μM) targeting Arg43 within the polyarginine pocket. LIQ1 exhibits efficacy in a mouse model of LPS (HY-D1056)-induced endotoxemia, preventing the nuclear translocation of PKM2 and inhibiting its binding to HIF-1α, thereby suppressing IL-1β transcription. LIQ1 can be used for the research of endotoxemia [1].
Cat. No.: HY-186271
CAS No.: 2148927-98-2
Target:
Research Areas:
TLR4 agonist-2 is a TLR4 agonist with EC50 values of 0.82 μM and 0.43 μM for mTLR4 and hTLR4, respectively. TLR4 agonist-2 induces the production of TLR4-dependent cytokines and chemokines. TLR4 agonist-2 can be used for immunological research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
