1 Result for "

LUNA 18

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "LUNA 18" in MCE Product Catalog:

LUNA18
LUNA18
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Cat. No.: HY-156002
CAS No.: 2676177-63-0
Purity:  99.20%
Synonyms: Paluratide
Target:  

Ras ERK

Research Areas:  

Cancer

LUNA18 is an orally-available cyclic peptide KRAS and ERK inhibitor. LUNA18 phosphorylates ERK and AKT and decreases cell proliferation in RAS-mutated cancer cells. LUNA18 exhibits RAS signal inhibition and potent anti-cancer activities through inhibiting interaction between RAS and guanine nucleotide exchange factors (GEFs) in a mouse xenograft model. LUNA18 shows significant cellular efficacy against cell lines with KRAS genetic alterations, such as colon cancer, stomach cancer, non-small cell lung cancer and pancreaticcancer .
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