9 Results for "

MED1

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "MED1" in MCE Product Catalog:

Cat. No.: HY-N10508
CAS No.: 71204-89-2
Calcitroic acid is a water-soluble terminal vitamin D metabolite and also a ligand for vitamin D receptor (VDR). Calcitroic acid binds to the ligand-binding domain of VDR, forms a retinoic X receptor complex, recruits the coactivator peptide MED1, mediates partial VDR-dependent transcription, inhibits Calcitriol (HY-10002)-induced VDR activation, and reduces the transcription level of CYP24A1 in the presence of 1α,25-dihydroxyvitamin D3. Calcitroic acid exerts selective activating effects on VDR, upregulates the expression of CYP24A1 and CYP3A4, decreases the transcription levels of iNOS and IL-1β, reduces the secretion of nitric oxide and IL-1β, and possesses metabolic stability due to its resistance to phase I oxidation and hepatic glucuronidation. Calcitroic acid can be used in research related to colon cancer, inflammatory bowel disease and rickets [1] .
loading...
    loading...
Cat. No.: HY-RS08278
Research Areas:  

Others

MED1 Human Pre-designed siRNA Set A contains three designed siRNAs for MED1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS18247
Research Areas:  

Others

Med1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Med1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS24727
Research Areas:  

Others

Med1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Med1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS08184
Research Areas:  

Others

MBD4 Human Pre-designed siRNA Set A contains three designed siRNAs for MBD4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS22462
Research Areas:  

Others

Cwc15 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cwc15 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-N10508S
CAS No.: 1637678-42-2
Calcitroic acid-13C is the 13C-labeled Calcitroic acid (HY-N10508). Calcitroic acid is a water-soluble terminal vitamin D metabolite and also a ligand for vitamin D receptor (VDR). Calcitroic acid binds to the ligand-binding domain of VDR, forms a retinoic X receptor complex, recruits the coactivator peptide MED1, mediates partial VDR-dependent transcription, inhibits Calcitriol (HY-10002)-induced VDR activation, and reduces the transcription level of CYP24A1 in the presence of 1α,25-dihydroxyvitamin D3. Calcitroic acid exerts selective activating effects on VDR, upregulates the expression of CYP24A1 and CYP3A4, decreases the transcription levels of iNOS and IL-1β, reduces the secretion of nitric oxide and IL-1β, and possesses metabolic stability due to its resistance to phase I oxidation and hepatic glucuronidation. Calcitroic acid can be used in research related to colon cancer, inflammatory bowel disease and rickets [1] .
loading...
    loading...
Cat. No.: HY-P85872
Synonyms: MEDiator of RNA polymerase II transcription subunit 1; Activator-recruited cofactor 205 kDa component; ARC205; MEDiator complex subunit 1; Peroxisome proliferator-activated receptor-binding protein; PBP; PPAR-binding protein; Thyroid hormone receptor-associated protein complex 220 kDa component; Trap220; Thyroid receptor-interacting protein 2; TR-interacting protein 2; TRIP-2; Vitamin D receptor-interacting protein complex component DRIP205;

Host:  

Mouse

Application:  

WB, ICC/IF, ELISA

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-RS19616
Research Areas:  

Others

Mbd4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mbd4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...