1 Result for "

Methyl cholate (Standard)

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Methyl cholate (Standard)" in MCE Product Catalog:

Methyl cholate (Standard)
Methyl cholate (Standard)
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Cat. No.: HY-107830R
CAS No.: 1448-36-8
Category:  

Microorganisms Steroids

Target:  

Reference Standards Endogenous Metabolite Collagen

Methyl cholate (Standard) is the analytical standard of Methyl cholate. This product is intended for research and analytical applications. Methyl cholate is a bile acid analog and a specific inhibitor of TcdB toxin from Clostridioides difficile. Methyl cholate exerts a stronger selective inhibitory effect on TcdB than on TcdA. Methyl cholate induces conformational stabilization by binding to a unique site of TcdB, thereby blocking the binding of the toxin to host receptors and its self-processing process. Methyl cholate effectively protects human fibroblasts from TcdB-induced cytopathic effects. Methyl cholate exhibits dose-dependent anti-hepatic fibrosis activity in both cellular and zebrafish models, and significantly reduces the expression levels of α-SMA and COL-I. Methyl cholate is suitable for in-depth research in the fields of Clostridioides difficile infection and hepatic fibrosis .
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