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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
NR4A2
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "NR4A2" in MCE Product Catalog:
Cat. No.: HY-174340
Target:
Research Areas:
Nurr1 agonist 13 (Compound 1) is a potent nuclear receptor related 1 (Nurr1, NR4A2) agonist with an EC50 value of 0.06 μM. Nurr1 agonist 13 is promising for research of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis .
Cat. No.: HY-RS09551
Target:
Research Areas:
NR4A2 Human Pre-designed siRNA Set A contains three designed siRNAs for NR4A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17344
Target:
Research Areas:
Nr4a2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nr4a2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23798
Target:
Research Areas:
Nr4a2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nr4a2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P71765
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NR4A2; NGFI-B/Nur77 Beta-Type Transcription Factor Homolog; Prev. NURR1; Nur Related Protein-1, Human Homolog Of; TINUR; Orphan Nuclear Receptor NR4A2 Isoform 1; NOT; Orphan Nuclear Receptor NR4A2 Isoform 2; HZF-3; Intermediate-Early Receptor Protein; RNR
Species:
Source:
Cat. No.: HY-179528
CAS No.: 2595179-74-9
Target:
Nuclear Hormone Receptor 4A/NR4A Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) Transferrin Receptor Apoptosis Bcl-2 Family Caspase
Research Areas:
DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist with KD values of 7.7 μM and 12.0 μM for NR4A1 and NR4A2, respectively. DIM-3,5-Cl2 acts as an inverse agonist to downregulate pro-oncogenic and proendometriotic gene products, and as an agonist to enhance NR4A1/2/Sp1/Sp4-mediated CD71 transactivation. DIM-3,5-Cl2 induces ferroptosis via ROS formation, lipoperoxidation, MDA production, and reduced GPX4, SLC7A11 expression. DIM-3,5-Cl2 induces apoptosis via PARP and caspase-3 cleavage, reduced BCL-2 expression, and inhibits cancer cell viability. DIM-3,5-Cl2 can be used for the research of triple negative breast cancer, endometriosis, and colorectal cancer .
Cat. No.: HY-P811347
Synonyms: NOT, NURR1, TINUR, NR4A2, Nuclear receptor subfamily 4 group A member 2, Immediate-early response protein NOT, Orphan nuclear receptor NURR1, Transcriptionally-inducible nuclear receptor
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
