NURR1 Antibody
(Synonyms: NOT, NURR1, TINUR, NR4A2, Nuclear receptor subfamily 4 group A member 2, Immediate-early response protein NOT, Orphan nuclear receptor NURR1, Transcriptionally-inducible nuclear receptor)NURR1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to NURR1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-2000 |
Product Details
NURR1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to NURR1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 60 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 66 kDa
Synthetic peptide corresponding to the Central region of human NURR1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NURR1 is a Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity)[1][2].
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Subcellular Localization
Cytoplasm; Nucleus
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Expression
Tissue_Specificity: Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. -
Isoforms & Post-Translational Modification
NURR1 has 2 isoforms, P43354-1: amino acid length is 598, molecular weight is 66591 Da (predicted); P43354-2: amino acid length is 535, molecular weight is 59809 Da (predicted).
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Subunit
Interacts with SFPQ, NCOR2, SIN3A and HADC1.
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SwissProt ID
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Synonyms
NOT, NURR1, TINUR, NR4A2, Nuclear receptor subfamily 4 group A member 2, Immediate-early response protein NOT, Orphan nuclear receptor NURR1, Transcriptionally-inducible nuclear receptor
Documentation
References
[1]. Flaig R, et al. Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domain. J Biol Chem. 2005 May 13;280(19):19250-8. [Content Brief]
[2]. Messmer K, et al. Induction of tyrosine hydroxylase expression by the transcription factor Pitx3. Int J Dev Neurosci. 2007 Feb;25(1):29-37. [Content Brief]
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