1 Result for "

Nef-M1

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Nef-M1" in MCE Product Catalog:

Cat. No.: HY-P10971
CAS No.: 860401-80-5
Research Areas:  

Cancer

Nef-M1 (Nef-Motif-1) is an antagonist peptide targeting CXCR4 and an apoptosis inducer derived from a myristoylated protein encoded by the nef gene in HIV. Nef-M1 inhibits tumor angiogenesis and epithelial-mesenchymal transition (EMT). Nef-M1 activates the apoptosis pathway by increasing the level of caspase-3 in cancer cells. Nef-M1 simultaneously inhibits VEGF-A, p-GSK-3β and vimentin, and enhances E-cadherin, thereby inhibiting angiogenesis and EMT processes. Nef-M1 can be used in the study of colorectal cancer and breast cancer [1] .
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