2 Results for "

ORM6151

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "ORM6151" in MCE Product Catalog:

Cat. No.: HY-171792
Synonyms: ORM-6151
Research Areas:  

Cancer

BMS-986497 (ORM-6151) is a CD33-targeting antibody-conjugated GSPT1 degrader. BMS-986497 delivers the GSPT1 degrader SMol006 to CD33-expressing cells and induces GSPT1 protein degradation. BMS-986497 shows potential for research on acute myeloid leukemia (AML) .
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Cat. No.: HY-P9S0124
Synonyms: ORM-6151 Antibody; BMS-986497 Antibody

Research Areas:  

Cancer

Anti-CD33 Antibody (OR000283) (ORM-6151 Antibody; BMS-986497 Antibody) is an antibody targeting CD33. It is generated by grafting the FAb (H&L) sequence of Gemtuzumab (HY-P99971) onto an IgG1 Fc carrying the N297A mutation, which inhibits Fc-γR binding. Anti-CD33 Antibody (OR000283) can be used to construct degrader-antibody conjugates (DACs), such as ORM-6151 (HY-171792) .
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