Anti-CD33 Antibody (OR000283)
Based on 1 Customer Validation
Anti-CD33 Antibody (OR000283) (ORM-6151 Antibody; BMS-986497 Antibody) is an antibody targeting CD33. It is generated by grafting the FAb (H&L) sequence of Gemtuzumab (HY-P99971) onto an IgG1 Fc carrying the N297A mutation, which inhibits Fc-γR binding. Anti-CD33 Antibody (OR000283) can be used to construct degrader-antibody conjugates (DACs), such as ORM-6151 (HY-171792).
For research use only. We do not sell to patients.
- Purity : 99.00%
- Molecular Weight:145.488 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
In Vitro
Anti-CD33 Antibody (OR000283) conjugated to the GSPT1 degrader SMol006 (BMS-986497/ORM-6151) potently kills CD33-expressing AML cell lines and primary relapsed/refractory AML patient blasts with picomolar potency, while showing minimal toxicity to non-cancerous hematopoietic progenitor cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
Target
Siglec-3/CD33
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
Product Image
Application
ELISA, FACS, Functional assay
Verified Bioactivity
-
Loaded Anti-CD33 Antibody (OR000283) on ACH2 biosensor, can bind Siglec-3/CD33 Protein, Human (HEK293, HY-P73643 ) with an affinity constant of 8.988E-10 M as determined in BLI assay.
Chemical Information
-
Appearance Liquid
-
Molecular Weight 145.488 kDa
-
Color Colorless to off-white
-
SMILES
N/A
-
Synonyms
ORM-6151 Antibody; BMS-986497 Antibody
-
Shipping
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (257 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
[1].
Palacino J, et al. ORM-6151: a first-in-class, anti-CD33 antibody-enabled GSPT1 degrader for AML.
[2]. Izzo D, et al. Innovative payloads for ADCs in cancer treatment: moving beyond the selective delivery of chemotherapy. Ther Adv Med Oncol. 2025;17:17588359241309461. Published 2025 Jan 2. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-CD33 Antibody (OR000283) Related Classifications
HY-P9S0124 Related Classifications
Powered by Bioz
Keywords