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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
P450 2B4
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "P450 2B4" in MCE Product Catalog:
Cat. No.: HY-121946
CAS No.: 35512-29-9
Synonyms: 4-(4-Chlorophenyl)imidazole
Target:
Research Areas:
4-CPI (4-(4-Chlorophenyl)imidazole) is a CYP2B4 inhibitor with an IC50 of 0.11 μM and a Kd of 0.043 μM. The Ks of 4-CPI for cytochrome P450eryF (S93C/C154S mutant) is 9.4 μM, with no allosteric cooperative effect of ligand binding . 4-CPI binds to CYP2B4 at a 1:1 ratio, which induces substantial conformational changes in the enzyme's active pocket to form a closed crystal conformation (PDB:1SUO). 4-CPI can be used to investigate the flexibility of P450 active pockets, protein-ligand binding thermodynamics, and the allosteric mechanisms of P450 .
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