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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
PROTAC NAMPT Degrader31
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "PROTAC NAMPT Degrader31" in MCE Product Catalog:
Cat. No.: HY-187347
PROTAC NAMPT Degrader-31 is a PROTAC degrader that targets and degrades NAMPT by recruiting cereblon. It exhibits DC50 values of 9.31 nM and 12.54 nM against NAMPT in MDA-MB-231 and 4T1 cells, respectively, and an IC50 value of 15.05 nM for NAMPT enzymatic activity. PROTAC NAMPT Degrader-31 induces NAMPT degradation via the ubiquitin-proteasome system, inhibits NAMPT enzymatic activity, and reduces NAD + levels through the NAD + salvage pathway. It can be used in research related to triple-negative breast cancer .
Cat. No.: HY-187348
CAS No.: 1800487-38-0
Research Areas:
TT-03597 is a modified NAMPT inhibitor core derived from OT-82 (HY-136241), which serves as a target protein ligand for PROTACs targeting NAMPT. TT-03597 can be used for the synthesis of PROTAC NAMPT Degrader-31 (HY-187347) .
Cat. No.: HY-187380
Target:
Research Areas:
Pip-piperazine-CO-pip-CO-C2-Boc is a linker with a piperidine-piperazine-amide-piperidine scaffold and a succinyl group at the terminal, which can be used for the synthesis of PROTAC, such as PROTAC NAMPT Degrader-31 (HY-187347) .
Cat. No.: HY-187349
Research Areas:
E3 Ligase Ligand-linker Conjugate 241 is an E3 ligase ligand-linker conjugate that serves as a component of PROTAC, such as PROTAC NAMPT Degrader-31 (HY-187347). E3 Ligase Ligand-linker Conjugate 241 is applicable to research related to PROTAC synthesis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
