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Cat. No.: HY-187380

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Pip-piperazine-CO-pip-CO-C2-Boc

Pip-piperazine-CO-pip-CO-C2-Boc is a linker with a piperidine-piperazine-amide-piperidine scaffold and a succinyl group at the terminal, which can be used for the synthesis of PROTAC, such as PROTAC NAMPT Degrader-31 (HY-187347).

For research use only. We do not sell to patients.

Formula: C₂₃H₄₀N₄O₄
Molecular Weight:436.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pip-piperazine-CO-pip-CO-C2-Boc Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All PROTAC Linkers Isoforms :

In Vitro

Pip-piperazine-CO-pip-CO-C2-Boc serves as the linker for PROTAC NAMPT Degrader-31 (HY-187347)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 436.59
Formula C₂₃H₄₀N₄O₄
SMILES

O=C(C1CCN(CC1)C(CCC(OC(C)(C)C)=O)=O)N(CC2)CCN2C3CCNCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Song Y, et al. Discovery of a Potent NAMPT-Targeting PROTAC for the Suppression of Triple-Negative Breast Cancer via Macrophage Reprogramming. Journal of medicinal chemistry. 2026 Jul 23;69(14):16801-16818. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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