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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
Postantibiotic
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "Postantibiotic" in MCE Product Catalog:
Cat. No.: HY-174980
KPC-2-IN-3 (Compound 3b) is a KPC-2 inhibitor with IC50 of 0.533 μM and Kiof 0.194 μM. KPC-2-IN-3 has an antimicrobial activity against carbapenem-resistant K. pneumonia K47-25 and reduces bacterial count with a postantibiotic effect in synergy with Meropenem (HY-13678). KPC-2-IN-3 significantly reduces lung bacterial load in a murine pneumonia model .
Cat. No.: HY-106668
CAS No.: 58152-03-7
Synonyms: Sch 21420
Target:
Research Areas:
Isepamicin (Sch 21420) is an aminoglycoside antibacterial. Isepamicin has better activity against strains producing type I 6'-acetyltransferase. Isepamicin’s antibacterial spectrum includes Enterobacteriaceae and staphylococci. Anaerobes, Neisseriaceae and streptococci are resistant. Isepamicin exhibits a strong concentration-dependent bactericidal effect, a long post-antibiotic effect (several hours) and induces adaptive resistance .
Cat. No.: HY-168960
Research Areas:
ROS inducer 8 (Compound 11g) is the inhibitor for glutathione (GSH), that induces the ROS accumulation in Enterococcus faecalis, thereby exhibiting antibacterial activity. ROS inducer 8 disrupts the biofilm, inhibits S. aureus and E. faecalis with MIC of 8 μg/mL and 2 μg/mL, exhibits post-antibiotic effect. ROS inducer 8 exhibits low hemolytic toxicity to sheep erythrocytes (HC50 > 1280 μg/mL) .
Cat. No.: HY-184297
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Research Areas:
Topoisomerase II-IN-26 is a dual bacterial type II topoisomerase (Top II) inhibitor, with IC50 values of 0.081 μM and 0.093 μM against Staphylococcus aureus DNA gyrase and topoisomerase IV, respectively, and IC50 values of 0.906 μM and 0.103 μM against Escherichia coli DNA gyrase and topoisomerase IV, respectively. Topoisomerase II-IN-26 also shows high selectivity for human topoisomerase IIα. Topoisomerase II-IN-26 inhibits biofilm formation, reduces the metabolic activity of mature biofilms, exhibits activity against Staphylococcus aureus, MRSA strains, Escherichia coli and Acinetobacter baumannii, and possesses a post-antibiotic effect. Topoisomerase II-IN-26 can be used for the research of bacterial infections such as Staphylococcus aureus and MRSA .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
