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Pyrilamine

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1281
    Mepyramine maleate
    2 Publications Verification

    Pyrilamine maleate

    		 Histamine Receptor Neurological Disease Endocrinology
    Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pKd of 9.4 for H1 receptor.
    Mepyramine maleate
  • HY-B1281R
    Mepyramine maleate (Standard)

    Pyrilamine maleate (Standard)

    		 Reference Standards Histamine Receptor Neurological Disease Endocrinology
    Mepyramine maleate (Standard) is the analytical standard of Mepyramine maleate. This product is intended for research and analytical applications. Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pKd of 9.4 for H1 receptor.
    Mepyramine maleate (Standard)
  • HY-173344
    DB-10

    		p38 MAPK Neurological Disease
    DB-10 is a pro-agent of 3-nbutylphthalide (NBP) (HY-B0647). DB-10 has significantly high uptake ability via pyrilamine cationic transporters in the temperature and energy dependent manner in cells. DB-10 improves the survival rate of cells. DB-10 could rapidly convert into active original agent and increase the accumulation in the brain in vivo. DB-10 can be used for ischemic stroke study .
    DB-10
  • HY-118807A
    Mepyramine hydrochloride

    Pyrilamine hydrochloride

    		 Histamine Receptor Potassium Channel Neurological Disease Inflammation/Immunology
    Mepyramine hydrochloride (Pyrilamine hydrochloride) is a selective histamine H1 receptor antagonist and KCNQ channel inhibitor, with an IC50 of 12.5 μM against KCNQ2/Q3. Mepyramine hydrochloride shows no activity against allergic asthma in mice when used alone, but modulates the effect of JNJ 7777120 (HY-13508) on allergic asthma in mice; it inhibits the development of morphine physical dependence and increases histamine levels in mouse brains. Mepyramine hydrochloride can be used in studies related to seizures, convulsions, allergic asthma and morphine physical dependence .
    Mepyramine hydrochloride

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