6036-95-9
Chemical Structure
Mepyramine hydrochloride
Synonym(s): Pyrilamine hydrochloride
- CAS No.: 6036-95-9
- Formula:C17H24ClN3O
- Molecular Weight:321.84
InChIKey: JZNHNILSWLPPKO-UHFFFAOYSA-N
SMILES: COC(C=C1)=CC=C1CN(CCN(C)C)C2=NC=CC=C2.Cl
Biological Activity: Mepyramine hydrochloride (Pyrilamine hydrochloride) is a selective histamine H1 receptor antagonist and KCNQ channel inhibitor, with an IC50 of 12.5 μM against KCNQ2/Q3. Mepyramine hydrochloride shows no activity against allergic asthma in mice when used alone, but modulates the effect of JNJ 7777120 (HY-13508) on allergic asthma in mice; it inhibits the development of morphine physical dependence and increases histamine levels in mouse brains. Mepyramine hydrochloride can be used in studies related to seizures, convulsions, allergic asthma and morphine physical dependence[1][2][3][4].
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Mepyramine hydrochloride | Mepyramine hydrochloride (Pyrilamine hydrochloride) is a selective histamine H1 receptor antagonist and KCNQ channel inhibitor, with an IC50 of 12.5 μM against KCNQ2/Q3. Mepyramine hydrochloride shows no activity against allergic asthma in mice when used alone, but modulates the effect of JNJ 7777120 (HY-13508) on allergic asthma in mice; it inhibits the development of morphine physical dependence and increases histamine levels in mouse brains. Mepyramine hydrochloride can be used in studies related to seizures, convulsions, allergic asthma and morphine physical dependence. | |||||||||||||||||||||
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- [1]. Liu B, et al. Antihistamine mepyramine directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons. Neuropharmacology. 2008;54(4):629-639. [Content Brief]
- [2]. Beermann S, et al. Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation. PLoS One. 2012;7(1):e30285. [Content Brief]
- [3]. Dirikolu L, et al. Pyrilamine in the horse: detection and pharmacokinetics of pyrilamine and its major urinary metabolite O-desmethylpyrilamine. J Vet Pharmacol Ther. 2009;32(1):66-78. [Content Brief]
- [4]. Hui KS, et al.The effect of mepyramine on the development of morphine tolerance and physical dependence in mice. Life Sci. 1975 Sep 15;17(6):891-9. [Content Brief]
Keywords
