1 Result for "

REGN-421

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "REGN-421" in MCE Product Catalog:

Cat. No.: HY-P99925
CAS No.: 1192578-27-0
Synonyms: REGN421

Target:  

Notch

Research Areas:  

Metabolic Disease Cancer

Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively .
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