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Enoticumab

(Synonyms: REGN421)
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Based on 1 Customer Validation

Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.64%
  • CAS No.: 1192578-27-0
  • Molecular Weight:146.48 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Enoticumab
  • Enoticumab Chemical Structure
    Enoticumab Chemical Structure
CAS No.: 1192578-27-0
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Enoticumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • Enoticumab Chemical Structure
    1/16
  • Enoticumab