1 Result for "

RKER216

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "RKER216" in MCE Product Catalog:

Cat. No.: HY-P991855

Target:  

TGF-β Receptor

Research Areas:  

Metabolic Disease

RKER-216 is a human monoclonal IgG antibody inhibitor targeting ALK2 with a KD of 58.7 pM. RKER-216 reduces hepcidin transcription in Hep3B.RKER-216 competes with BMP ligands for binding to the extracellular domain of ALK2, thereby inhibiting BMP-SMAD signal. RKER-216 mobilizes tissue iron effectively in inflammatory conditions. RKER-216 improves microcytic anemia in a dose-dependent manner by inhibiting SMAD signaling to reduce hepcidin and promote iron absorption and utilization in vivo. RKER-216 can be used for research on anemia of inflammation .
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