1 Result for "

RLS-0071

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "RLS-0071" in MCE Product Catalog:

Pegtarazimod
Pegtarazimod
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Cat. No.: HY-P10868
CAS No.: 2056232-82-5
Synonyms: RLS-0071
Target:  

Reactive Oxygen Species (ROS)

Research Areas:  

Infection Inflammation/Immunology

Pegtarazimod (RLS-0071) is a dual-target anti-inflammatory peptide that exerts its effects by simultaneously regulating the complement system and neutrophil-associated inflammatory pathways. Pegtarazimod reduces ROS production both in vitro and in vivo, and decreases the level of neutrophil elastase, a marker of neutrophil extracellular traps (NETs), in vivo, thereby alleviating inflammatory responses. Pegtarazimod significantly improves the survival rate of mice in multiple in vivo models of acute graft-versus-host disease (aGVHD). Pegtarazimod inhibits the activation of the C1 complex, reduces the herpes zoster-like spread of herpes simplex virus type 1 skin infection, and improves the survival rate of infected mice . Pegtarazimod can be used in research related to acute graft-versus-host disease, acute pulmonary diseases, and skin herpes simplex virus type 1 infection .
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