2056232-82-5
Chemical Structure
Pegtarazimod
Synonym(s): RLS-0071
- CAS No.: 2056232-82-5
- Formula:C122H224N20O46S2
- Molecular Weight:2771.32
SMILES: O=C([C@@H](N)[C@H](CC)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)C)=O)C)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)CCC(N)=O)=O)CS)=O)CS)=O)[C@H](CC)C)=O)CCC1)=O)CCC(O)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)CC(C)C)=O)C
Biological Activity: Pegtarazimod (RLS-0071) is a dual-target anti-inflammatory peptide that exerts its effects by simultaneously regulating the complement system and neutrophil-associated inflammatory pathways. Pegtarazimod reduces ROS production both in vitro and in vivo, and decreases the level of neutrophil elastase, a marker of neutrophil extracellular traps (NETs), in vivo, thereby alleviating inflammatory responses. Pegtarazimod significantly improves the survival rate of mice in multiple in vivo models of acute graft-versus-host disease (aGVHD). Pegtarazimod inhibits the activation of the C1 complex, reduces the herpes zoster-like spread of herpes simplex virus type 1 skin infection, and improves the survival rate of infected mice. Pegtarazimod can be used in research related to acute graft-versus-host disease, acute pulmonary diseases, and skin herpes simplex virus type 1 infection[1][2][3].
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Pegtarazimod | Pegtarazimod (RLS-0071) is a dual-target anti-inflammatory peptide that exerts its effects by simultaneously regulating the complement system and neutrophil-associated inflammatory pathways. Pegtarazimod reduces ROS production both in vitro and in vivo, and decreases the level of neutrophil elastase, a marker of neutrophil extracellular traps (NETs), in vivo, thereby alleviating inflammatory responses. Pegtarazimod significantly improves the survival rate of mice in multiple in vivo models of acute graft-versus-host disease (aGVHD). Pegtarazimod inhibits the activation of the C1 complex, reduces the herpes zoster-like spread of herpes simplex virus type 1 skin infection, and improves the survival rate of infected mice. Pegtarazimod can be used in research related to acute graft-versus-host disease, acute pulmonary diseases, and skin herpes simplex virus type 1 infection. | |||||||||||||||||||||
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- [1]. Verena Holzmüller, et al. Exploring a Novel Anti-Inflammatory Peptide As a Potential Treatment for Acute Graft-Versus-Host Disease (aGVHD). Volume 144, Supplement 1, 5 November 2024, Page 3399
- [2]. Jessica Goss, et al. RLS-0071, a dual-targeting anti-inflammatory peptide - biomarker findings from a first in human clinical trial. Volume 8, article number 1, (2023)
- [3]. Bhutta MS, et al. Peptide Inhibitor of Complement C1, RLS-0071, Reduces Zosteriform Spread of Herpes Simplex Virus Type 1 Skin Infection and Promotes Survival in Infected Mice. Viruses. 2021;13(8):1422. Published 2021 Jul 22. [Content Brief]
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