2 Results for "

SMRT peptide

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "SMRT peptide" in MCE Product Catalog:

Cat. No.: HY-P10543
CAS No.: 857026-08-5
Target:  

BCL6

Research Areas:  

Cancer

SMRT peptide is one of the co-repressors of BCL6 BTB domain interaction. SMRT peptide binds to the BTB domain of BCL6 and enhances the transcriptional repression function of BCL6. SMRT peptide can be used to study protein-protein interactions .
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Cat. No.: HY-148640
CAS No.: 2253985-29-2
Research Areas:  

Cancer

WK500B is a potent and orally active BCL6 inhibitor with a KD of 1.61 μM. WK500B engages intracellular BCL6 and disrupts BCL6‑corepressor interactions to reactivate BCL6 target genes. WK500B exerts cytotoxicity against diffuse large B‑cell lymphoma cells and induces apoptosis and cell cycle arrest. WK500B suppresses germinal center formation in C57BL/6 mice and DLBCL tumor growth in SCID xenograft models without observable toxicity. WK500B can be used for the study of diffuse large B‑cell lymphoma (DLBCL) .
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