5 Results for "

TRPC3-IN-1

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "TRPC3-IN-1" in MCE Product Catalog:

Cat. No.: HY-185477
CAS No.: 2767260-24-0
Target:  

TRP Channel

Research Areas:  

Neurological Disease

TRPC3-IN-1 is a human transient receptor potential canonical 3 (hTRPC3) inhibitor with an IC50 of 0.09 μM. TRPC3-IN-1 inhibits hTRPC3-mediated currents. TRPC3-IN-1 is applicable to research related to diseases such as epilepsy .
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3
3 Cited Publications
Cat. No.: HY-P2141
CAS No.: 1234510-46-3
Synonyms: TRV027
Research Areas:  

Cardiovascular Disease

TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages β-arrestins while blocking G-protein signaling . TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R-β-arrestin-1-TRPC3-PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment .
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3
3 Cited Publications
Cat. No.: HY-P2141A
Research Areas:  

Cardiovascular Disease

TRV120027 TFA, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ?-arrestins while blocking G-protein signaling . TRV120027?TFA induces?acute?catecholamine?secretion?through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the?acute decompensated heart failure (ADHF) treatment .
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1
1 Cited Publications
Cat. No.: HY-12504
CAS No.: 245747-08-4
Purity:  98.47%
Synonyms: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridINecarboxamide
Target:  

CRAC Channel

Research Areas:  

Others

Pyr6 is a selective store operated calcium entry (SOCE) inhibitor with an IC50 of 0.49 μM. Pyr6 displays 37-fold higher potency for RBL SOCE than for TRPC3 ROCE .
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Cat. No.: HY-179489
CAS No.: 1589567-51-0
Target:  

TRP Channel

Research Areas:  

Others

TRPC3 agonist-1 (compound 4n) is a selective and competitive TRPC3 channel agonist. TRPC3 agonist-1 binds at L2 site of hTRPC3 .
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