1 Result for "

Tg-AD

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Tg-AD" in MCE Product Catalog:

Cat. No.: HY-179723
CAS No.: 3083425-61-7
Target:  

GSK-3 Tau Protein

Research Areas:  

Neurological Disease

GSK3β-IN-4 is a selective, potent, orally active and brain-penetrant ATP-competitive GSK3β inhibitor with an IC50 of 0.37 nM. GSK3β-IN-4 shows an IC50 of 2.75 nM and SI of 7.4 for GSK3α. GSK3β-IN-4 reduces tau phosphorylation at Ser396 by inhibiting GSK3β and imoroves cognitive deficits in Alzheimer's disease models. GSK3β-IN-4 can be used for the research of Alzheimer's disease .
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