3083425-61-7
Chemical Structure
GSK3β-IN-4
- CAS No.: 3083425-61-7
- Formula:C26H26N4O2
- Molecular Weight:426.51
InChIKey: XAXOABQDRHTDKX-MRXNPFEDSA-N
SMILES: O=C(C1CCCC1)NC2=C3C(C4=CC=C(C(N[C@@H](C5=CC=CC=C5)C)=O)C=C4N3)=CC=N2
Biological Activity: GSK3β-IN-4 is a selective, potent, orally active and brain-penetrant ATP-competitive GSK3β inhibitor with an IC50 of 0.37 nM. GSK3β-IN-4 shows an IC50 of 2.75 nM and SI of 7.4 for GSK3α. GSK3β-IN-4 reduces tau phosphorylation at Ser396 by inhibiting GSK3β and imoroves cognitive deficits in Alzheimer's disease models. GSK3β-IN-4 can be used for the research of Alzheimer's disease[1].
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GSK3β-IN-4 | GSK3β-IN-4 is a selective, potent, orally active and brain-penetrant ATP-competitive GSK3β inhibitor with an IC50 of 0.37 nM. GSK3β-IN-4 shows an IC50 of 2.75 nM and SI of 7.4 for GSK3α. GSK3β-IN-4 reduces tau phosphorylation at Ser396 by inhibiting GSK3β and imoroves cognitive deficits in Alzheimer's disease models. GSK3β-IN-4 can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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Keywords
