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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
Thiorphan
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "Thiorphan" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-W013375
CAS No.: 76721-89-6
Target:
Research Areas:
Thiorphan is a selective neprilysin (NEP) inhibitor with an IC50 of 6.9 nM. Thiorphan competitively binds to NEP and blocks its activity, preventing the degradation of neuropeptides such as substance P (SP) and neurokinin NKA. In the field of neonatal brain injury research, Thiorphan can increase the levels of SP and NKA, activate NK1 and NK2 receptors and downstream transduction pathways, and inhibit excessive activation of NMDA receptors. Thus, Thiorphan can protect neocortical neurons from excitotoxic cell death. Thiorphan may also inhibit NEP from enhancing bronchoconstriction and can be used in the study of respiratory diseases .
3
Target:
Research Areas:
Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent .
Cat. No.: HY-W013375S
CAS No.: 1276297-68-7
Cat. No.: HY-W013375S1
CAS No.: 2183240-70-0
Cat. No.: HY-144378S
CAS No.: 1346603-29-9
Cat. No.: HY-CE01954
Synonyms: Thiorphan-coenzyme A
Target:
Research Areas:
Thiorphan-CoA (Thiorphan-coenzyme A) is a coenzyme A derivative .
Cat. No.: HY-114635
CAS No.: 112573-72-5
Synonyms: Retorphan
Target:
Research Areas:
Dexecadotril (Retorphan) is a powerful and selective neprilysin (NEP) inhibitor. Dexecadotril is a prodrug of the R-enantiomers of Thiorphan (HY-W013375). Dexecadotril shows intestinal antisecretatory action .
Cat. No.: HY-17399S
CAS No.: 1246815-11-1
Synonyms: Acetorphan-d5
Cat. No.: HY-17399R
CAS No.: 81110-73-8
Synonyms: Acetorphan (Standard)
Target:
Research Areas:
Racecadotril (Standard) is the analytical standard of Racecadotril. This product is intended for research and analytical applications. Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent .
Cat. No.: HY-144230S
CAS No.: 1398044-41-1
Cat. No.: HY-126991
CAS No.: 80970-04-3
Target:
Research Areas:
Leu-thiorphan is an active compound.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
