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Urolithin M5

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Urolithin M5" in MCE Product Catalog:

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Urolithin M5
Urolithin M5
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Cat. No.: HY-N7922
CAS No.: 91485-02-8
Synonyms: Decarboxyellagic acid
Category:  

Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae

Target:  

Influenza Virus p38 MAPK EGFR Akt Reactive Oxygen Species (ROS) Apoptosis

Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC50 values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease .
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