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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
Val-Ala dipeptide
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "Val-Ala dipeptide" in MCE Product Catalog:
1
Cat. No.: HY-164729
Cat. No.: HY-42709
CAS No.: 24787-89-1
Synonyms: Carbobenzoxy-L-Valyl-L-Alanine
Target:
Research Areas:
Cat. No.: HY-P4658
CAS No.: 87810-63-7
Target:
Research Areas:
Cat. No.: HY-W007035R
CAS No.: 27493-61-4
Synonyms: Valyl-Alanine (Standard)
Cat. No.: HY-W007035S
Synonyms: Valyl-Alanine-13C5,15N TFA
Cat. No.: HY-183253
Research Areas:
DL149 is a component of an antibody-drug conjugate (ADC) formed by conjugating the eIF4A inhibitor FD236 (HY-186186) with an ADC linker, and exhibits potential antitumor activity. DL149 can bind to an anti-HER2 antibody to form a complete ADC molecule, which precisely binds to the HER2 receptor on the surface of tumor cells. After internalization into cells, it releases the eIF4A inhibitor payload. DL149 irreversibly blocks the mRNA translation process in tumor cells, thereby inhibiting tumor cell proliferation and inducing their death. DL149 exhibits in vivo antitumor activity in the SK-OV-3 xenograft tumor model, and can be used for the research of HER2-positive solid tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
