1 Result for "

WX2-43

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "WX2-43" in MCE Product Catalog:

Cat. No.: HY-W072962
CAS No.: 723754-14-1
Research Areas:  

Cancer

WX2-43 is a PRMT5-KLF4 inhibitor (Kd of 11.0 nM). WX2-43 binds to the region between amino acids L400-M500 on PRMT5. WX2-43 efficiently intercepts the interaction between KLF4 and PRMT5, and blocks KLF4 methylation. WX2-43 decreases p21 levels and increases Bax levels. WX2-43 suppresses triple negative breast tumor progression. WX2-43 can be used in the research of triple-negative breast cancer and colorectal cancer .
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