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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
ZFP-91
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "ZFP-91" in MCE Product Catalog:
Cat. No.: HY-159570
CAS No.: 2710221-08-0
Research Areas:
XD2-149 is a ZFP91 PROTAC degrader with DC50 values of 0.08 μM and 0.06 μM, respectively. ZFP91 is a bifunctional nuclear protein with both transcription factor and E3 ubiquitin ligase activities, and is classified as an oncogenic non-canonical NF-κB pathway regulator in tumor and immune regulation. XD2-149 induces proteasome-dependent degradation of the E3 ubiquitin-protein ligase ZFP91. XD2-149 inhibits the STAT3 signaling pathway in pancreatic cancer cells and induces NQO1-dependent cell death independent of ZFP91 degradation. XD2-149 can be used for the research of pancreatic cancer .
Cat. No.: HY-RS16046
Target:
Research Areas:
ZFP91 Human Pre-designed siRNA Set A contains three designed siRNAs for ZFP91 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-177725
CAS No.: 2413733-33-0
Target:
Research Areas:
MG degrader 2 (Compound CM-2) is a CRBN-dependent molecular glue degrader. MG degrader 2 induces ZFP91, FIZ1 and PI4KB degradation. MG degrader 2 has anti-proliferative activity against MM.1S cells (IC50 = 162 nM). MG degrader 2 can be used for the research of cancer, such as multiple myeloma .
Cat. No.: HY-172368
Research Areas:
PROTAC IKZF3 degrader-1 is a potent dual-targeting agent that functions as both a CARM1 inhibitor (IC50 = 2 nM) and a CRBN-dependent PROTAC degrader of IKZF3. PROTAC IKZF3 degrader-1 simultaneously inhibits CARM1 activity (reducing BAF155 methylation) and recruits CRBN to induce the targeted degradation of IKZF1, IKZF3, ZFP91, and FGD3 proteins; this leads to the downregulation of oncogenes, more potent induction of apoptosis, and the overcoming of immunomodulatory imide drugs resistance. PROTAC IKZF3 degrader-1 is suitable for research into both IMiD-sensitive and IMiD-resistant multiple myeloma .
Cat. No.: HY-173256
Research Areas:
Hyp-dBET1 is a hypoxia-activated BRD4 PROTAC degrader. The IC50 of Hyp-dBET1 for reducing cell viability under hypoxic conditions is approximately 153 nM to 192 nM, while it shows low activity under normoxic conditions (IC50 of approximately 2.8 μM to 3.8 μM). Hyp-dBET1 induces BRD4 degradation under hypoxic conditions, converts to dBET1 in hypoxic environments, and downregulates the expression level of ZFP-91. Hyp-dBET1 can be used in studies related to breast cancer, cervical cancer and solid tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
