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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
dBET 1
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "dBET 1" in MCE Product Catalog:
20
20 Cited Publications
Target:
Research Areas:
dBET1 is a PROTAC connected by ligands for Cereblon and BRD4 with an EC50 of 430 nM. dBET1 is a PROTAC that composes of (+)-JQ1 (HY-13030) linked to NSC 527179 (HY-14658) with a linker .
Cat. No.: HY-173255
Target:
Research Areas:
DAO-dBET1 is a Dual-Action-Only PROTAC containing a PROTAC degrader, dBET1 (HY-101838). DAO-dBET1 is a potent BRD4 degrader with a DC50 value of 277 nM in the presence of CoCl2. DAO-dBET1 inhibits hypoxia and Cath-L trigger with an IC50 value of 281 nM .
Cat. No.: HY-101838R
CAS No.: 1799711-21-9
Research Areas:
dBET1 (Standard) is the analytical standard of dBET1 (HY-101838). This product is intended for research and analytical applications. dBET1 is a PROTAC connected by ligands for Cereblon and BRD4 with an EC50 of 430 nM. dBET1 is a PROTAC that composes of (+)-JQ1 (HY-13030) linked to NSC 527179 (HY-14658) with a linker .
Cat. No.: HY-173256
Research Areas:
Hyp-dBET1 is a hypoxia-activated BRD4 PROTAC degrader. The IC50 of Hyp-dBET1 for reducing cell viability under hypoxic conditions is approximately 153 nM to 192 nM, while it shows low activity under normoxic conditions (IC50 of approximately 2.8 μM to 3.8 μM). Hyp-dBET1 induces BRD4 degradation under hypoxic conditions, converts to dBET1 in hypoxic environments, and downregulates the expression level of ZFP-91. Hyp-dBET1 can be used in studies related to breast cancer, cervical cancer and solid tumors .
Cat. No.: HY-173257
Target:
Research Areas:
Cath-L-dBET1 is a PROTAC degrader targeting BRD4. Cath-L-dBET1 has an IC50 value of 2.8 μM in MDA-MB-231 cells. Cath-L-dBET1 can be activated by cathepsin L (Cath-L) and recruit the E3 ubiquitin ligase and degrade BRD4 through ubiquitin-proteasome system. Hyp-dBET1 can be used for anti-tumor study .
Cat. No.: HY-178092
Target:
Research Areas:
Boc-(S)-Lys(Ac)-NH(4-CHO-Ph) is a PROTAC linker. Boc-(S)-Lys(Ac)-NH(4-CHO-Ph) can be used to synthesize the PROTAC Cath-L-dBET1 (HY-173257).
Cat. No.: HY-178094
CAS No.: 1101702-81-1
Target:
Ligands for Target Protein for PROTAC Target Protein Ligand-Linker Conjugates Epigenetic Reader Domain
Research Areas:
BRD4 ligand 13 is a BRD4 ligand that can be used for the synthesis of PROTACs, such as Cath-L-dBET1 (HY-173257). BRD4 ligand 13 is a target protein ligand-conjugate that can be used for the synthesis of PROTACs, such as SJH1-51B (HY-162240) .
Cat. No.: HY-178091
CAS No.: 1995701-00-2
Synonyms: NO2-Ph-C-NH-C4-NHBoc
Target:
Research Areas:
Boc-4-NBA-butyl (NO2-Ph-C-NH-C4-NHBoc) is a PROTAC linker. NO2-Ph-C-NH-C4-NHBoc can be used to synthesize the PROTAC Hyp-dBET1 (HY-173256).
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
