3 Results for "

endothiapepsin

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "endothiapepsin" in MCE Product Catalog:

13
Icatibant acetate
Icatibant acetate
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13 Cited Publications
Cat. No.: HY-108896
CAS No.: 138614-30-9
Purity:  99.85%
Synonyms: HOE 140 acetate
Target:  

Bradykinin Receptor

Research Areas:  

Inflammation/Immunology

Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively .
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CP-69799
CP-69799
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Cat. No.: HY-P1609
CAS No.: 105116-61-8
Target:  

Renin Enteropeptidase

Research Areas:  

Cardiovascular Disease

CP-69799 is an azahomostatine-containing oligopeptide transition-state analogue inhibitor with a hog renin IC50 of 6e-9 M, human plasma renin IC50 of 3e-7 M and Ki of 0.310 μM, and endothiapepsin Ki of 0.27 μM. CP-69799 binds endothiapepsin’s active site cleft in extended conformation, fills S4 to S3' pockets, displaces native solvent molecules, induces domain rotation, and reduces thermal mobility of endothiapepsin’s flap and helix regions. CP-69799 acts as a transition-state analogue inhibitor of hog renin and human plasma renin. CP-69799 contains a polar lysine residue at the P2' position, with a nitrogen atom replacing the P1' Cα atom of the hydroxyethylene dipeptide isostere. CP-69799 can be used for the research of hypertension .
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CP 81282
CP 81282
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Cat. No.: HY-117641
CAS No.: 121584-61-0
Target:  

Ser/Thr Protease

Research Areas:  

Cardiovascular Disease

CP 81282 is a tripeptide aspartic protease inhibitor, with an IC50 of 1 nM against human renin and an IC50 of 11 nM against endopeptidase. CP 81282 is applicable to the research of hypertension .
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