CP 81282
CP 81282 is a tripeptide aspartic protease inhibitor, with an IC50 of 1 nM against human renin and an IC50 of 11 nM against endopeptidase. CP 81282 is applicable to the research of hypertension.
For research use only. We do not sell to patients.
- CAS No.: 121584-61-0
- Formula: C32H47F2N5O6
- Molecular Weight:635.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
CP 81282 potently inhibits human plasma renin with an IC50 of 1 nM and endothiapepsin with an IC50 of 11 nM[1].
CP 81282 binds to endothiapepsin as a tetrahedral hydrate, forming specific hydrogen bonds with active-site aspartates 32 and 215, and adopts an extended conformation that interacts with additional enzyme residues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 121584-61-0
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Molecular Weight 635.74
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Formula C32H47F2N5O6
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SMILES
CNC(C(F)(C(C(NC(C(NC(C(CC1=CC=CC=C1)NC(N2CCOCC2)=O)=O)CCCC)=O)CC3CCCCC3)=O)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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