2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. CP 81282

CP 81282 is a tripeptide aspartic protease inhibitor, with an IC50 of 1 nM against human renin and an IC50 of 11 nM against endopeptidase. CP 81282 is applicable to the research of hypertension.

For research use only. We do not sell to patients.

CP 81282

CP 81282 Chemical Structure

CAS No. : 121584-61-0

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CP 81282 Related Antibodies

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Description

CP 81282 is a tripeptide aspartic protease inhibitor, with an IC50 of 1 nM against human renin and an IC50 of 11 nM against endopeptidase. CP 81282 is applicable to the research of hypertension[1].

In Vitro

CP 81282 potently inhibits human plasma renin with an IC50 of 1 nM and endothiapepsin with an IC50 of 11 nM[1].
CP 81282 (10-fold molar excess) binds to endothiapepsin as a tetrahedral hydrate, forming specific hydrogen bonds with active-site aspartates 32 and 215, and adopts an extended conformation that interacts with additional enzyme residues[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CP 81282 Related Antibodies
Molecular Weight

635.74

Formula

C32H47F2N5O6
CAS No.
SMILES

CNC(C(F)(C(C(NC(C(NC(C(CC1=CC=CC=C1)NC(N2CCOCC2)=O)=O)CCCC)=O)CC3CCCCC3)=O)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CP 81282 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP 81282121584-61-0CP81282CP-81282Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteaseshuman reninactive-site aspartates 215catalytic aspartate residuesaspartic proteinasesactive-site aspartates 32amide bond cleavage intermediateshuman plasma reninhypertensionaspartic proteinase active sitesendothiapepsinInhibitorinhibitorinhibit

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