1 Result for "

fsrBDC

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "fsrBDC" in MCE Product Catalog:

Siamycin I
Siamycin I
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Cat. No.: HY-P2200
CAS No.: 164802-68-0
Synonyms: BMY-29304
Target:  

HIV Antibiotic

Research Areas:  

Infection Inflammation/Immunology

Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED50s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research .
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