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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
hSTING oligomerization
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "hSTING oligomerization" in MCE Product Catalog:
Cat. No.: HY-171012
CAS No.: 21829-22-1
Synonyms: NSC 335504
Target:
Research Areas:
Clonixeril (NSC 335504) is a non-nucleotide hSTING modulator. Clonixeril has weak agonist activity at micromolar concentrations and results in antagonism of the hSTING WT pathway at low femtomolar (10 -15 M) and in some cases even attomolar (10 -18 M) concentrations. Clonixeril reduces hSTING oligomerization at a concentration of 1 aM-1 pM .
Cat. No.: HY-184502
CAS No.: 3034295-80-9
Target:
Research Areas:
DDO-88109 is a STING inhibitor with a Kd value of 317 nM for hSTING and 0.625 μM for mSTING. DDO-88109 competitively occupies the CDN-binding pocket of STING, thereby maintaining STING in an inactive state. It inhibits cGAS-STING signaling—including STING translocation from the endoplasmic reticulum to the Golgi apparatus, STING oligomerization, and the phosphorylation of IRF3, p65, TBK1, and STING—and attenuates the production of inflammatory cytokines and tissue inflammation in mouse models of TREX1-deficiency-driven autoinflammation and cisplatin (HY-17394)-induced acute kidney injury. DDO-88109 is suitable for research on inflammatory diseases, autoimmune disorders, and acute kidney injury driven by the cGAS-STING pathway .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
