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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
hypervascular malignancies
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "hypervascular malignancies" in MCE Product Catalog:
Cat. No.: HY-183849
CAS No.: 1932672-71-3
Research Areas:
H9‑KGDEVD‑MMAE is a component of antibody‑drug conjugate (ADC) conjugated via a linker cleavable by cathepsin B and caspase-3/7 to Monomethyl auristatin E (HY‑15162), a potent tubulin inhibitor. H9-KGDEVD-MMAE binds to PRND to enable precise drug delivery to tumor vasculature and cancer cells. H9-KGDEVD-MMAE induces apoptosis, produces a bystander effect, and disrupts tumor vasculature. H9-KGDEVD-MMAE achieves deep tumor penetration and exhibits durable anti-tumor efficacy without systemic toxicity in preclinical models of highly vascularized malignant tumors. H9-KGDEVD-MMAE can be applied to research related to glioblastoma, sarcoma, and renal cell carcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
