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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
hypoxia detection
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "hypoxia detection" in MCE Product Catalog:
Cat. No.: HY-D3075
CAS No.: 2490504-23-7
Target:
Research Areas:
TPE-2E N-oxide is a fluorescent probe used for hypoxia detection and tumor hypoxia imaging. Due to its active intramolecular motion, TPE-2E N-oxide shows no fluorescence in aqueous solution. In hypoxic environments, its N-oxide group undergoes two-electron reduction by CYP450 reductase and other heme protein reductases expressed under hypoxia, forming hydrophobic aggregates that trigger aggregation-induced emission through the restriction of intramolecular motion. TPE-2E N-oxide exhibits selective lipid droplet localization in cells. The absorption wavelength of TPE-2E N-oxide in dichloromethane is 313 nm; in a 99% hexane/dichloromethane mixed system, its excitation wavelength is 330 nm and emission wavelength is 460 nm. For in vitro cell imaging, excitation is performed at 405 nm, with an emission wavelength range of 430-560 nm .
Cat. No.: HY-116156
CAS No.: 167648-73-9
Target:
Research Areas:
SR-4554 is a probe for the measurement of tumor hypoxia. SR-4554 undergoes enzymatic single-electron reduction reactions within hypoxic cells. SR-4554 determines the 19F retention index for four commonly used mouse tumors (EMT6, SCCVII, KILT and RIF-I) through 19F MRS technique. SR-4554 can used to detect tumor Hypoxia noninvasively by 19F magnetic resonance spectroscopy ( 19F MRS) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
