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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
interferon regulatory factor 3
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "interferon regulatory factor 3" in MCE Product Catalog:
Cat. No.: HY-174136
Research Areas:
STING Degrader-2 is an orally active STING degrader that promotes proteasome-independent degradation of STING. STING Degrader-2 inhibits cGAMP-induced STING activation, suppresses STING oligomerization, and inhibits phosphorylation of STING and interferon regulatory factor 3 (IRF3). STING Degrader-2 reduces serum IFN-β and CXCL-10 levels in a cGAMP-induced autoimmune disease mouse model. STING Degrader-2 can be used for the research of autoimmune diseases .
Cat. No.: HY-174308
Target:
Research Areas:
ZSA-215 is a potent and orally active STING agonist with an EC50 of 3.3 μM. ZSA-215 enhances STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β. ZSA-215 inhibits tumor regression and long-term survival of mice in MC38 colon cancer model. ZSA-215 can be used to the study of colon cancerr .
Cat. No.: HY-P702766
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IRF3; interferon regulatory factor 3c; interferon regulatory factor 3; interferon regulatory factor 3d; interferon regulatory factor 3, Isoform CRA_b; interferon regulatory factor 3e; interferon regulatory factor 3a; IRF3 Protein; interferon regulatory Fa
Cat. No.: HY-P71747
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IRF3; interferon regulatory factor 3c; interferon regulatory factor 3; interferon regulatory factor 3d; interferon regulatory factor 3, Isoform CRA_b; interferon regulatory factor 3e; interferon regulatory factor 3a; IRF3 Protein; interferon regulatory Fa
Species:
Source:
Cat. No.: HY-P81022AA
Synonyms: interferon regulatory factor 3, IRF-3, IRF3
Cat. No.: HY-181526
CAS No.: 3099101-40-0
Research Areas:
Sim-9 is a covalent allosteric inhibitor of interferon regulatory factor 3 (IRF3). Sim-9 binds covalently to the Cys222 residue of IRF3, induces its conformational change, blocks its interactions with TRIF, MAVS and STING, and inhibits IRF3 homodimerization and type I interferon response. Sim-9 exhibits significant anti-inflammatory, organ-protective and survival benefits in mouse models of sepsis and acute pancreatitis. Sim-9 can be used for research related to inflammatory diseases .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
